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Both medications can cause gastrointestinal side effects such as nausea, vomiting, and diarrhoea, which may be more pronounced when used together

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Mental Health Concerns Like Suicidal Thoughts Mental health concerns became an issue of importance with GLP-1 agonists when the Food and Drug Administrations Adverse Event Reporting System received numerous reports of individuals who reported suicidal thoughts and ideations while taking GLP-1 agonist drugs

Nord J Psychiatry 70:561562 Fink-Jensen A, Wrtwein G, Klausen MK et al (2024) Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male Vervet monkeys